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Set several years after "The Great Uprising", a future geological phenomenon near Tokyo, people have developed a power granting them the ability to deconstruct, reshape, and crystalize matter at a molecular level using only thought and willpower. These people have come to be known as "Alter" users. With only 1% of the newborn generations receiving such special power, though this number rises steadily as the series progresses, some feel a superiority over normal humans.
There are two opposing forces of alters: the Native Alters, a group of Alter users who live outside the central city and avoid any relationships with the government; and HOLY, an organization of Alter users that are a subgroup of an organization called HOLD. HOLD functions as the Mainland government's super police force of the Lost Ground, while HOLY, composed exclusively of Alter users, serves as the 'special operations' group, aiding HOLD in performing dangerous missions that might require the help of an Alter user.

